Colistimethate sodium is a medication used in the treatment of serious bacterial infections, particularly those caused by multidrug-resistant Gram-negative bacteria. It belongs to a class of drugs known as polymyxins.

Colistimethate sodium works by disrupting the bacterial cell membrane, leading to the death of susceptible bacteria. It is effective against certain bacteria, including Pseudomonas aeruginosa and Klebsiella pneumoniae, that are resistant to many other antibiotics.


The medication is typically administered by injection, either intravenously or intramuscularly. The specific dosage and treatment duration are determined by the healthcare provider based on the type and severity of the infection, as well as the patient’s individual factors.

Common side effects of colistimethate sodium may include kidney toxicity, neurotoxicity (nerve damage), and respiratory problems. Regular monitoring of kidney function and other parameters may be necessary during treatment.


Colistimethate sodium should only be used under the guidance and prescription of a qualified healthcare professional experienced in the treatment of bacterial infections. It may interact with other medications, so it is important to inform the healthcare provider about all medications being taken, including over-the-counter drugs and supplements.

In summary, colistimethate sodium is a medication used in the treatment of serious bacterial infections caused by multidrug-resistant Gram-negative bacteria. It disrupts the bacterial cell membrane to kill susceptible bacteria. Regular monitoring and adherence to healthcare provider instructions are important during colistimethate sodium treatment.

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